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Charcot-Leyden Crystals drive pathology and inflammation in muco-obstructive lung disease
2025-11-27
allergy and immunology
Title + abstract only
View on medRxiv
Show abstract
Mucus plugging leading to airway obstruction is a hallmark of chronic respiratory diseases, yet the biology of plugs and their contribution to airway inflammation remain poorly defined. Through guided retrieval and analysis of plugs from patients with allergic bronchopulmonary aspergillosis, we identify Charcot-Leyden crystals that are formed from eosinophil-derived Galectin-10 as ubiquitous and mechanistic components that generate highly localized type 2 inflammatory niches. These niches exhibi...
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