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Merging Adaptive Designs with Dynamic Infectious Disease Models Allows Faster and more Accurate Diagnostic Test Accuracy Studies in the Case of an Epidemic

2025-11-27 epidemiology Title + abstract only
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BackgroundDuring epidemics with emerging infections, diagnostic tests directly inform model-based decision-making and thereby shape infection control strategies. However, diagnostic accuracy studies (DTA) assessing the validity of these tests must be conducted under severe time and data constraints. We investigated whether the integration of adaptive designs and of epidemic spread modelling for prevalence prediction can accelerate DTA studies during epidemics with emerging infections without com...

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