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Cortico-Pallidal Beta Dynamics Underlie Impaired Turning in Parkinson's Disease

Shukla, P. D.; Bath, J. E.; Louie, K. H.; Fekri Azgomi, H.; Patelaki, E.; Marks, J.; Balakid, J.; Wang, D. D.

2025-11-27 neurology
10.1101/2025.11.25.25340849 medRxiv
Show abstract

Turning while walking is one of the most common yet complex human movements, and it is frequently impaired in Parkinsons disease (PD), leading to falls and loss of independence. The neural mechanisms underlying this difficulty remain unclear. Using chronically implanted devices that simultaneously record and stimulate the brain, we measured activity in the motor cortex and basal ganglia of individuals with PD during natural walking and turning. Successful turns were marked by reduced beta-band activity and flexible communication between cortical and pallidal regions, whereas impaired turns showed excessive beta synchrony that rigidly constrained movement. Medication and deep brain stimulation improved turning through distinct circuit mechanisms, dopamine suppressing abnormal pallidal beta activity and its communication with the cortex, and stimulation restoring cortical flexibility. These findings reveal how dynamic cortical-basal ganglia interactions enable complex movement and establish circuit targets for adaptive brain stimulation to reduce falls in PD.

Published in npj Parkinson's Disease (predicted rank #5) · training set

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