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Population-scale multiome immune cell atlas reveals complex disease drivers

2025-11-27 genetic and genomic medicine Title + abstract only
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Most genetic variants associated with complex diseases lie in non-coding regions, yet mechanistic insights have been limited by the lack of an empirical framework for characterizing the molecular consequences of regulatory variation. Single-cell profiling of molecular quantitative trait loci (QTL) can connect variants to gene regulation, but prior studies lacked the sample size to detect variants at disease-relevant genes and the simultaneous measurements across regulatory layers needed to trace...

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