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Pupil size reveals the perceptual quality and effortless nature of synesthesia

Strauch, C.; Leenaars, C.; Rouw, R.

2025-11-26 neuroscience
10.1101/2025.11.24.690102 bioRxiv
Show abstract

Synesthesia describes cross-modal processes that can generate extra conscious percepts, such as seeing additional color when reading numbers. While existing research focuses on the mechanisms and effects of synesthetic associations, it often overlooks its most distinctive feature: unique sensory phenomenology. Here, we introduce pupillometry as an objective physiological measure of synesthetic color phenomenology. Across 16 grapheme-color synesthetes and two matched control groups, pupil responses tracked the brightness of synesthetic colors under constant physical visual input, scaling with self-reported strength. Synesthetic colors elicited pupil dynamics comparable to real colors, dissociating synesthetes from non-synesthetes. These responses emerged too rapidly to reflect imagery and scaled with reported color bright-ness, revealing cross-modally caused genuine perceptual processing. Controls required to generate color associations showed greater effort-linked pupil di-lation than synesthetes or controls who did not report colors, providing evidence for the effortless nature of synesthesia. Synesthesia thus provides an extraordinarily tractable human model for studying physiologically measurable phenomenology.

Published in eLife (predicted rank #2) · training set

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