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Clinical validation of an HPV whole genome sequencing assay for molecular residual disease detection in HPV-associated head and neck cancer patients treated with surgery
2025-11-27
oncology
Title + abstract only
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BackgroundSurgery is a common treatment for early-stage HPV-associated head and neck squamous cell carcinoma (HPV+HNC). Selection of patients who require adjuvant treatment is based on clinicopathologic risk factors, which have poor individualized prognostic capacity. Circulating tumor HPV DNA (ctHPVDNA) is a highly sensitive and specific biomarker for HPV+HNC at diagnosis, but current clinically available assays lack the necessary sensitivity for accurate minimal residual disease (MRD) detectio...
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