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Decomposing genetic effects of social connectedness and depression on youth behaviors and long-term clinical outcomes.

2025-11-23 psychiatry and clinical psychology Title + abstract only
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ImportanceLacking social connectedness is associated with broad morbidity. Yet the underlying mechanisms remain obscures, especially given its entanglement with depressive symptoms. Clarifying whether social connectedness confers unique risk beyond depression can guide clinical care and social infrastructure interventions. ObjectiveTo decompose shared genetic architecture between social connectedness and depressive affect, derive independent polygenic liabilities, and test their differential as...

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