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Betrayal and unfairness are linked through insula-valuation network dynamics

Stanley, J. M.; Dwamena, D.; Wyngaarden, J. B.; Kos, M.; Jarcho, J.; Fareri, D.; Smith, D. V.

2026-06-12 neuroscience
10.1101/2025.11.20.689349 bioRxiv
Show abstract

Trust and fairness sustain cooperation, but social neuroscience has largely studied violations of these social norms in isolation. We asked whether neural sensitivity to betrayal carries forward into the evaluation of unfairness in a separate social exchange. In 132 adults who completed fMRI during the Trust Game and Ultimatum Game, betrayal and unfairness both recruited overlapping voxels within left anterior insula. Yet, individual differences in regional activation were uncorrelated across tasks, arguing against a simple shared-response account. Instead, cross-task structure emerged in connectivity: stronger anterior insula responses to social versus nonsocial betrayal predicted weaker anterior insula-ventromedial prefrontal coupling during social versus nonsocial fairness evaluation. These findings suggest that betrayal and unfairness are linked less by identical regional responses than by how salience signals engage valuation circuitry across contexts. By bridging two canonical social exchange tasks within the same individuals, this study reveals a network-level architecture for generalizing sensitivity to interpersonal norm violations.

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