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Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19

2025-11-21 intensive care and critical care medicine Title + abstract only
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In susceptible patients, COVID-19 causes life-threatening disease driven by immune-mediated inflammatory lung injury. We have previously shown that multiple common host genetic variants are significantly associated with susceptibility to critical Covid-19, 1;2;3 and in one case, we demonstrated that such variants can inform development of new, effective drug treatment1;4. Here we report an association analysis of whole-genome sequences (WGS) from 11,423 cases from the GenOMICC study and 60,628 c...

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