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Associations between sickle haemoglobin and the Plasmodium falciparum CLAG and FIKK gene families revealed by meta-analysis of 6,289 African samples
2025-11-19
infectious diseases
Title + abstract only
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The recent discovery that mutations in the Plasmodium falciparum genome are overrepresented in infections of sickle haemoglobin (HbS)-carriers has highlighted new questions about the underlying biological and evolutionary interaction, yet the full extent of this association is unknown. By meta-analysing host and parasite data from N=6,289 infections, including 831 newly sequenced samples from The Gambia, we implicate several new parasite genome regions in the interaction, including within the CL...
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