Crosstalk of noradrenergic Ca2+ and cAMP signaling in astrocytes of the murine olfactory bulb
Sauer, J.; Beiersdorfer, A.; Schmidt, F. L.; Nordbeck, M.; Constantin, O.; Hirnet, D.; Gee, C. E.; Lohr, C.
Show abstract
Cyclic adenosine monophosphate (cAMP) and Ca2+ are ubiquitous second messengers that regulate gene expression, metabolism, and synaptic plasticity. Here, we identified a complex interplay between Ca2+ and cAMP signaling pathways in mouse olfactory bulb astrocytes. Norepinephrine (NE) elevated both Ca2+ and cAMP levels via 1 and 2 adrenergic receptors, whereas {beta} receptors triggered only cAMP responses. The 1 receptor agonist phenylephrine increased cAMP, but this effect was suppressed when Ca2+ elevations were blocked by Ca2+ depletion and removal of external Ca2+. We found that 1A and 1D receptors are key targets for phenylephrine, acting through Ca2+/calmodulin-dependent adenylyl cyclases AC1 and AC3 downstream of 1 receptor activation. Moreover, 2 receptor stimulation raised Ca2+ levels, thereby stimulating cAMP production, yet also reduced forskolin-induced cAMP elevations, indicating that 2 receptors can both inhibit adenylyl cyclase via Gi and stimulate AC1/AC3 via Ca2+ signaling. Together, these findings reveal intricate crosstalk between noradrenergic Ca2+ and cAMP signaling in olfactory bulb astrocytes mediated by all three adrenergic receptor subtypes.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning 95%
- Distinct release properties of glutamate/GABA co-transmission serve as a frequency-dependent filtering of supramammillary inputs 95%
- Strikingly different neurotransmitter release strategies in dopaminergic subclasses 95%
Similar papers in this journal
- Deletion of calcineurin from GFAP-expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na+/K+ ATPase. 95%
- Norepinephrine activates β1-adrenergic receptors localized to the inner nuclear membrane in cortical astrocytes 95%
- K+ efflux through postsynaptic NMDA receptors suppresses local astrocytic glutamate uptake 94%
Similar papers in this journal
- Coordinated regulation of CB1 cannabinoid receptors and anandamide metabolism stabilizes network activity during homeostatic scaling down 95%
- Cell-type specificity of neuronal excitability and morphology in the central amygdala 94%
- Dopamine D2 receptors modulate intrinsic properties and synaptic transmission of parvalbumin interneurons in the mouse primary motor cortex 94%
Similar papers in this journal
- Anandamide reduces excitability by preferentially targeting somatic VGSCs via CB1 95%
- Norepinephrine acts through radial astrocytes in the developing optic tectum to enhance threat detection and escape behavior 95%
- Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.