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T cell tolerant fraction as a predictor of graft-vs-host disease following allogeneic hematopoietic cell transplantation
2025-11-10
transplantation
Title + abstract only
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BackgroundDonor T cell reconstitution following allogeneic hematopoietic cell transplantation (HCT) is crucial for protective immunity against infections and cancer relapse. However, its use remains limited by the risk of graft-versus-host disease (GvHD), a serious complication arising when donor T cells target recipient tissues. Here we evaluate a novel metric--the T cell receptor beta (TRB) tolerant fraction--as a predictor of GvHD risk. MethodsWe analyzed TRB sequencing data from mouse model...
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