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Peripheral transcriptomic signature of chronic antibody-mediated rejection in kidney transplantation: a dual effect for MMP9 over time

2025-11-07 transplantation Title + abstract only
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BACKGROUNDChronic antibody-mediated rejection (CAMR) is the main cause of late kidney allograft loss, and no specific effective treatment has been identified so far. Here, we proposed to explore the non-invasive peripheral blood transcriptome signature of CAMR. METHODSFirst, we compared PBMC gene expression from bulk RNA-seq between 35 patients experiencing late CAMR (mean=7.1 years) vs. 43 patients without graft dysfunction at late stages (Stable, mean=4.4 years) to identify the molecular driv...

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