Random crosslinks generate anomalous scaling of dynamic modulus of biomolecular condensates
Lyu, B.; Lin, J.
Show abstract
Biomolecular condensates are viscoelastic, and their mechanical properties are intimately related to their biological functions. However, the connection between microscopic networks formed by intermolecular crosslinks and viscoelasticity is still elusive. Here, we model biomolecular condensates as random crosslinked polymer solutions to elucidate how random connectivity fundamentally alters their viscoelasticity. We decompose the entire solution into multiple tree networks and demonstrate that for networks with size n, their spectra of relaxation rates{lambda} exhibit a power-law scaling pn({lambda}) [~]{lambda} -1/3 with a lower cutoff{lambda} min [~] n-3/2. By integrating all networks, we show that for the entire solution, random crosslinks generate an abundance of soft modes involving multiple linear polymers with a flat spectrum of relaxation rates. The soft modes cause anomalous linear frequency scaling of the dynamic modulus, in particular, they significantly boost the low-frequency storage modulus relative to uncrosslinked systems. Our predictions agree quantitatively with the experimental data from distinct biomolecular condensates.
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