Ultra-long-range Polycomb-coupled interactions underlie subtype identity of human cortical neurons
Pletenev, I. A.; Vaulin, N.; Molodova, M. N.; Kuznechenkova, E.; Soldatenkova, A.; Efimova, O. I.; Tvorogova, A. V.; Khaitovich, P.; Razin, S. V.; Ulianov, S. V.; Khrameeva, E. E.
Show abstract
Regulation of gene expression by Polycomb group (PcG) proteins orchestrates neural development and cell-type specification. However, the mechanisms by which neural progenitor cells diversify into the myriad cell types of the human brain remain poorly understood. Here, we investigate the role of Polycomb pro-teins in shaping the single-cell 3D genome, transcriptome, and chromatin binding landscape of the developing and adult human cortex. We show that PcG proteins establish a network of long-range repressive interactions encompassing loci with neuronal marker genes. These interactions occur in a neuron-type-dependent manner, selectively targeting genes that must remain silenced in a given cell type. These interactions are present in fetal neurons and increase markedly in strength after birth. Our results highlight PcG proteins as key regulators of neuronal cell fate specification in the human brain.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model 95%
- Human ORC/MCM density is low in active genes and correlates with replication time but does not solely define replication initiation zones 94%
- The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements 94%
Similar papers in this journal
- Histone H3.3 lysine 9 and 27 control repressive chromatin states at cryptic cis-regulatory elements and bivalent promoters in mouse embryonic stem cells 94%
- Connecting high-resolution 3D chromatin organization with epigenomics 94%
- Boosting the detection of enhancer-promoter loops via novel normalization methods for chromatin interaction data 94%
Similar papers in this journal
- Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes 95%
- G-quadruplexes are promoter elements controlling nucleosome exclusion and RNA polymerase II pausing 94%
- In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.