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The Evaluation of Tenecteplase for the Treatment of an Ischemic Stroke

2025-11-07 neurology Title + abstract only
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IntroductionFor more than two decades, the standard for thrombolysis for Acute Ischemic Stroke (AIS) has been alteplase 0.9 mg/kg (maximum 90 mg) with 10 % given as a bolus. More recent studies such as the EXTEND-IA, and AcT study have shown tenecteplase (TNK) may have potential advantages over alteplase for AIS. In November 2024 the ATTEST-2 study was published with the largest comparative prospective study to date. This study included 1858 patients from 39 stroke centers in the UK which were r...

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