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Genome-wide association study reveals two novel genetic loci associated with chronic lung allograft dysfunction
2025-11-07
transplantation
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BackgroundChronic lung allograft dysfunction (CLAD) leads to declining respiratory function and high mortality, representing the main barrier to long-term survival in lung transplantation (LT). We performed the first genome-wide association study (GWAS) investigating donors and recipients genetic factors associated with CLAD. MethodWe genotyped 392 donor-recipient pairs from the multicentric Cohort in Lung Transplantation. We tested 4.5 million SNPs for association with CLAD using multivariable...
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