Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation
Carroll, S. L.; Ly, A.; Liu, A. K.; Canesso, M. C. C.; Victora, G. D.; Mucida, D.; Barton, G. M.
Show abstract
How the complex network of intestinal antigen presenting cells (APCs) instructs CD4+ T cell responses against the microbiota remains unclear. Here, we use Labeling Immune Partnerships by SorTagging Intercellular Contacts (LIPSTIC) to characterize the APCs that prime CD4+ T cells recognizing the commensal bacterium Akkermansia muciniphila. A. muciniphila-specific T cells engaged multiple transcriptionally distinct migratory cDC2 subpopulations, both at homeostasis, when A. muciniphila promotes TFH differentiation, and during inflammation, when it also drives TH1 and TH17 differentiation. The identity of these subpopulations was unchanged by inflammation; however, the distribution of presentation across the subpopulations shifted, with increased presentation by inflammatory cDC2s favoring TH1 and TH17 polarization. These results reveal how distinct T cell differentiation trajectories can be determined through varied interactions with multiple, functionally distinct subpopulations of APCs.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Populations with Unique Homology to Thymic Epithelium 97%
- cDC1 Coordinate Innate and Adaptive Responses in the Omentum required for T cell Priming and Memory 97%
- Pathogenic IgE-fated memory B cell responses retain functional plasticity 96%
Similar papers in this journal
Similar papers in this journal
- A gut commensal protist protects against virus-mediated loss of oral tolerance 97%
- Antigen receptor signaling and cell death resistance controls intestinal humoral response zonation. 96%
- BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen 96%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.