Umbilical Cord Blood Cell Transcriptional and Methylation Signatures at Birth Are Associated with BPD Development.
Liu, Q.; Helmin, K. A.; Bailey, J.; Perez-Leonor, X. G.; Phan, D.; Abdala-Valencia, H.; Mithal, L. B.; Singer, B. D.; Robbins, M. E.; Perez, M.
Show abstract
Bronchopulmonary dysplasia (BPD) is the most common respiratory disease in preterm infants born at less than 28 weeks gestation. Most existing clinical prediction models for BPD show limited accuracy in predicting BPD development when validated using external data, stressing the need for novel biomarkers to identify at-risk infants for early and effective interventions. We leveraged existing frozen umbilical cord blood samples from the Northwestern University Cord Blood Biobank (NUCord) to perform parallel transcriptional and DNA methylation profiling. BPD-associated differentially expressed genes (DEGs) in our cohort included markers previously established in clinical and animal BPD studies, such as genes related to NF-{kappa}B signaling and immune responses. We also identified that BPD development is associated with disrupted methylation signatures in microRNA genes and genes associated with glucose metabolism. Our results suggest that BPD development is associated with distinct transcriptomic and epigenetic signatures when compared with healthy term and preterm infants. These signatures may represent biomarkers measurable at birth that predict BPD development during a time window when preventative or therapeutic interventions could be applied.
Matching journals
The top 13 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Placental microRNA Expression Associates with Birthweight through Control of Adipokines: Results from Two Independent Cohorts 93%
- Immune pathways and perinatal environmental exposures contribute to epigenetic gestational age prediction and acceleration 91%
- Genome-wide study of the effect of blood collection tubes on the cell-free DNA methylome 90%
Similar papers in this journal
- Sex Differences in the Risk of Bronchopulmonary Dysplasia and Pulmonary Hypertension: A Bayesian Meta-Analysis 93%
- Early, low-dose hydrocortisone and near-term brain connectivity in extremely preterm infants 91%
- Minimum Effective Dose of Clemastine in a Mouse Model of Preterm White Matter Injury 89%
Similar papers in this journal
- Large-scale placenta DNA methylation mega-analysis reveals fetal sex-specific differentially methylated CpG sites and regions 92%
- Genetic Polymorphisms Associated with Adverse Pregnancy Outcomes in Nulliparas 91%
- Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: The Framingham Heart Study 90%
Similar papers in this journal
- Multi-omic brain and behavioral correlates of cell-free fetal DNA methylation in macaque maternal obesity models 93%
- Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth 92%
- Perinatal Inflammation Influences but Does Not Arrest Rapid Immune Development in Preterm Babies 91%
Similar papers in this journal
- Expression quantitative trait methylation analysis reveals methylomic associations with gene expression in childhood asthma 89%
- Obstructive sleep apnea is associated with specific gut microbiota species and functions in the population-based Swedish CardioPulmonary bioImage Study (SCAPIS) 88%
- Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap 87%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.