Non-invasive 2H-MRS reveals a greater liver fat contribution from de novo lipogenesis in South Asians compared with Europeans
Azhar, M.; Worsley, J.; Dennis, K. M. J. H.; De Lucia Rolfe, E.; Barrett, A.; Mandour, M. O.; Demir, E.; Carr, K.; Ferraro, M.; De Jesus, R.; King, S.; Jose, S.; White, S. R.; Barker, P.; Kemp, G. J.; Brindle, K. M.; Chatterjee, K. K.; Forouhi, N. G.; Venables, M.; Watson, L.; Hodson, L.; Savage, D. B.; Sleigh, A.
Show abstract
Understanding the role of de novo lipogenesis (DNL) in human liver fat accumulation and insulin resistance has been hampered by a lack of non-invasive techniques capable of quantifying DNL-derived liver lipid. Here we develop a precise method that utilises deuterium magnetic resonance imaging, capable of detecting human 2H liver lipid signal changes in vivo due to DNL. We formulate MR-specific DNL equations and use these to determine if DNL accounts for the increased liver fat and metabolic risk previously reported in South Asians, compared with age- and BMI- matched individuals from European ancestry. We find an increased fraction of liver fat originates from DNL in South Asians, and that this strongly relates to the amount of liver fat and composition, implying DNL or related factors could play a pivotal role in driving the increased liver fat in South Asians.
Matching journals
The top 1 journal accounts for 50% of the predicted probability mass.
Similar papers in this journal
- Accuracy and reliability of an MR-compatible dorsiflexion ergometer for dynamic 31P-MRS: Comparison with a clinical dynamometer in individuals with and without obesity 94%
- Cardiac metabolic imaging using hyperpolarized lactate as a substrate 93%
- Band-selective IR PRESS for brain tumor spectroscopy allows robust detection of lactate 92%
Similar papers in this journal
- Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct ( 2 H) and indirect ( 1 H) detection of deuterium labeled compounds at 7T and clinical 3T 93%
- Spontaneous Neural Activity Changes after Bariatric Surgery: a resting-state fMRI study 93%
- Neuroanatomical Changes in White and Grey Matter after Sleeve Gastrectomy 93%
Similar papers in this journal
- Insulin sensitivity is preserved in mice made obese by feeding a high starch diet 93%
- Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability 92%
- Maternal diet-induced obesity during pregnancy alters lipid supply to fetuses and changes the cardiac tissue lipidome in a sex- dependent manner 92%
Similar papers in this journal
- Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis 93%
- Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice 92%
- Dietary isoleucine content defines the metabolic and molecular response to a Western diet 92%
Similar papers in this journal
- Two years later – changes in abdominal organs: First observations from the UK Biobank longitudinal imaging study 93%
- Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice. 92%
- Imaging the Transmembrane and Transendothelial Sodium Gradients in Gliomas 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.