Pneumococcal pneumonia in adults - Re-emergence of vaccine serotypes: a prospective multicentre cohort study in Germany, 2020-2023
Bahrs, C.; Rose, N.; Barten-Neiner, G.; Fleischmann-Struzek, C.; van der Linden, M. P.; Rohde, G.; Rupp, J.; Witzenrath, M.; Rademacher, J.; Pletz, M. W.
10.1101/2025.10.24.25338303 medRxivShow abstract
This prospective multicentre study investigated pneumococcal serotype distribution and vaccine coverage of the 13- and 20-valent conjugate vaccines, and the 23-valent polysaccharide vaccine among adults with community-acquired pneumonia in Germany, from 2020 to 2023, using serotype-specific urine antigen detection testing. The findings show that Streptococcus pneumoniae has reemerged as causative pathogen of pneumonia, particularly in adults aged [≥]60 years. This resurgence, observed during the ongoing SARS-CoV-2 pandemic, has been primarily driven by an increase in cases due to serotype 3.
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