Identity and functions of monoaminergic neurons in the predatory nematode Pristionchus pacificus reveal nervous system conservation and divergence
Loer, C. M.; Yim, H.; Geiger, L. T.; Ramadan, Y. H.; Hampton, M. F.; Bernal, D. V.; Carstensen, H. R.; Morgan, J.; Rivard, L.; Medina, T.; Cook, S. J.; Okumura, M.; Lightfoot, J. W.; Hobert, O.; Hong, R. L.
Show abstract
Changes in neurotransmitter usage in homologous neurons may drive evolutionary adaptations in neural circuits across animal phylogeny. The predatory nematode Pristionchus pacificus can be used as a model system to examine nervous system evolution by comparing neurotransmitter expression with that of C. elegans and other nematodes. Here we characterize P. pacificus neurotransmitter expression and function in specific neurons, focusing on its complete set of monoaminergic neurons. We discover patterns of conservation as well as novelties. We examine the roles of monoamines in specific behaviors using neurotransmitter synthesis and vesicular transporter mutants, finding possible differences in the control of host-finding and dispersal behavior.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence 97%
- CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression 96%
- daf-16/FOXO blocks adult cell fate in Caenorhabditis elegans dauer larvae via lin-41/TRIM71 96%
Similar papers in this journal
- Visualizing the organization and differentiation of the male-specific nervous system of C. elegans 97%
- Shaking hands is a putative terminal selector and controls axon outgrowth of central complex neurons in the insect model Tribolium 96%
- NHR-23 activity is necessary for C. elegans developmental progression and apical extracellular matrix structure and function 96%
Similar papers in this journal
- Caenorhabditis elegans junctophilin has tissue-specific functions and regulates neurotransmission with extended-synaptotagmin 97%
- Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in C. elegans 96%
- The X chromosome is a potential polarising signal for asymmetric cell divisions in meiotic cells of a nematode 96%
Similar papers in this journal
- The Voltage-gated sodium channel in Drosophila, Para, localizes to dendrites as well as axons in mechanosensitive chordotonal neurons 96%
- A novel and specific regulator of neuronal V-ATPase in Drosophila 95%
- The G-protein coupled receptor SRX-97 is required for concentration dependent sensing of Benzaldehyde in Caenorhabditis elegans 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.