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Task-related Aperiodic EEG (1/f) Activity in Autism

Matyjek, M.; Soto Faraco, S.; Alvarez Martin, C.; Torralba Cuello, M.

2025-10-17 psychiatry and clinical psychology
10.1101/2025.10.16.25338172 medRxiv
Show abstract

Autism has been hypothesised to involve atypicalities in the balance between neural excitation and inhibition (E/I). Aperiodic EEG activity, characterised by the 1/f exponent of the power spectrum, provides a proxy of cortical E/I dynamics, yet prior studies in autism report mixed findings. One potentially important modulator of EEG slope is task engagement. Here, we examined variations in aperiodic slopes in autistic (n = 35) and neurotypical (n = 39) adults during passive viewing and an active, goal-directed task. The data revealed that autistic participants exhibited steeper slopes (indicative of increased inhibition vs. excitation) during the active task relative to passive viewing, whereas neurotypical participants showed no significant task-related changes. These findings suggest that aperiodic activity reflects dynamic, task-dependent neural adaptation rather than baseline group differences. Task engagement may reveal compensatory inhibitory processes in autistic adults, underscoring the importance of considering task demands and individual variability when investigating E/I balance in autism.

Published in Autism Research (predicted rank #5) · training set

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