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Robust methylome analysis and tumour-normal classification in TCGA-COAD: a reproducible workflow

2025-10-17 oncology Title + abstract only
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Colorectal adenocarcinoma is caused in part by widespread epigenetic deregulation, yet the analysis of genome-wide DNA methylation of colorectal adenocarcinoma is complicated due to spatial correlation among CpG, multiscale patterns of differential methylation, and confounding cellular heterogeneity in bulk tissue. This study develops a simple yet effective framework that combines rigorous statistical modelling with modern machine learning-based prediction, on the Illumina 450K data from The Can...

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