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Greenspace, air pollution, and respiratory health outcomes: A systematic review of cohort studies

Vance, M. S.; Lane, T. J.; Ye, T.

2025-10-19 occupational and environmental health
10.1101/2025.10.16.25338155 medRxiv
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Exposure to greenspace is associated with improved health outcomes, with proposed mechanisms including improved local air quality and health effects that reduce personal susceptibility to air pollution. This systematic review synthesises cohort study evidence on whether greenspace protects against air pollution effects on respiratory-related health outcomes. We conducted a systematic review of cohort studies, searching Medline, Embase, and Scopus databases published up to December 2024. Study quality was evaluated using the Newcastle-Ottawa Scale. Twelve studies met the inclusion criteria, all of which were rated as "good" quality. Cohorts mostly originated from Europe, with outcomes including respiratory-related mortality, lung function, and non-infectious respiratory diseases. In general, exposure to greenspace was protective against air pollution-associated respiratory mortality, with effects more consistently detected through mediation than moderation. Residential greenspace appears to reduce the harm associated with air pollutants on respiratory health outcomes, including related mortality. The stronger association detected through mediation analysis suggests that the mechanism is through improvements in local air quality rather than the direct effects of greenspace on health to enhance individual resilience to the effects of air pollution. HighlightsO_LIThis systematic review investigated whether greenspace protects against respiratory health harms from air pollution C_LIO_LIWe identified 12 eligible cohort studies, all rated "good" quality C_LIO_LIResults mixed but generally suggested greenspace is protective C_LIO_LIMore consistent findings for mediated pathways, suggesting greenspace reduces pollution in local environment C_LI Visual Abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=111 SRC="FIGDIR/small/25338155v1_ufig1.gif" ALT="Figure 1"> View larger version (38K): org.highwire.dtl.DTLVardef@b1656forg.highwire.dtl.DTLVardef@7a6c34org.highwire.dtl.DTLVardef@155e0bcorg.highwire.dtl.DTLVardef@11563a2_HPS_FORMAT_FIGEXP M_FIG C_FIG

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