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Systems Vaccinology Reveals Distinct Immune Signatures of Inhaled and Intramuscular SARS-CoV-2 Vaccination in Humans
2025-10-15
allergy and immunology
Title + abstract only
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Mucosal vaccines may reduce both infection and transmission by engaging local immunity, yet the immunological pathways they activate in humans remain poorly defined. Here, we present a comprehensive systems vaccinology analysis of a Modified Vaccinia virus Ankara (MVA)-based SARS-CoV-2 vaccine candidate tested in two distinct phase 1 clinical trials as a booster vaccination with either inhaled or intramuscular delivery, and benchmarked findings against published mRNA vaccine data. Longitudinal m...
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