On the overlap of transcription factor binding and regulatory targets: functional and regulatory coherence of top-bound targets is masked by weakly bound ones
Mindel, V.; Barkai, N.
Show abstract
A recent study that systematically mapped genomic bindings and regulatory effects of transcription factors (TFs) reported a surprisingly low overlap between TF binding and regulatory targets in Saccharomyces cerevisiae1. Our analysis suggests that this conclusion depends on the permissive definition of binding targets, which includes a large fraction of weakly bound sites.
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