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Lower pre-treatment TMS-evoked cortical reactivity and alpha-band oscillatory dynamics predict efficacy of primary motor cortex neuromodulation for chronic pain

2025-10-14 pain medicine Title + abstract only
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Repetitive transcranial magnetic stimulation (rTMS) to the primary motor cortex (M1) provides significant pain relief in [~]45% of chronic pain patients. Identifying biomarkers that predict treatment response before starting rTMS is essential for guiding clinical decision-making. Here, we used TMS combined with electroencephalography (TMS-EEG) to assess pre-treatment cortical function in 43 patients with chronic pain before receiving 12 sessions of therapeutic 10 Hz rTMS to M1 over eight weeks a...

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