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Mitochondrial activity promotes neutrophil degranulation and endothelial dysfunction in systemic infections

2025-10-13 infectious diseases Title + abstract only
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Neutrophils are essential for defense against pathogens but excessive activation in systemic infections can drive immunopathology. We show that neutrophil degranulation can induce endothelial dysfunction via degradation of the glycocalyx and increase of endothelial permeability. To identify targetable pathways regulating neutrophil degranulation in severe inflammation, we compared the proteomes of neutrophils isolated from patients with severe malaria and sepsis. We found significant upregulatio...

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