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Impact of AKR1C2 and AKR1C3 single nucleotide polymorphism rs28571848 in adipose tissues of individuals with severe obesity
2025-10-14
genetic and genomic medicine
Title + abstract only
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BackgroundAdipose tissue androgen turnover, dictated at least in part by the enzymes AKR1C2 and AKR1C3, has been linked to abdominal obesity. Recently, we investigated a single-nucleotide polymorphism (SNP) named rs28571858, that might increase AKR1C2 and AKR1C3 expression in human adipose tissue. Here, we studied the impact of rs28571848 on adipose tissue function and cardiometabolic health in bariatric surgery candidates. MethodsWe genotyped a sample of 2776 bariatric surgery candidates and r...
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