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The impact of vaccine products, schedules and geographic regions on immunogenicity of pneumococcal vaccines in children under 2 years old: a systematic review and meta-analysis

2025-10-10 infectious diseases Title + abstract only
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BackgroundPneumococcal conjugate vaccines (PCVs) cover only a proportion of disease-causing serotypes. In some settings, population-level introduction of PCVs has resulted in an increase in "non-vaccine" serotype incidence. Higher-valency PCVs were developed to address shifting disease-causing serotypes. We aim to systematically define the trends in vaccine immunogenicity and likely protection over time. MethodsWe conducted a systematic review and meta-analysis of studies published to Jan 7, 20...

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