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Inhaled booster vaccination with an MVA-based SARS-CoV-2 vaccine candidate induces T cell responses in lung
2025-10-13
allergy and immunology
Title + abstract only
View on medRxiv
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BackgroundParenteral COVID-19 vaccines induce strong systemic immunity, but they do not typically trigger pronounced respiratory immunity. In this context, mucosally applied vaccines might help to induce local immune responses for early viral clearance and reduced viral transmission. MethodsIn this investigator-initiated, open-label single-dose phase I trial, we analyzed the immunogenicity and safety of the vaccine candidate MVA-SARS-2-ST administered as an inhalation boost in COVID-19-immunize...
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