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Integrative Analysis of GWAS and Single-Cell eQTL Data Identifies Immune Cell-Type-Specific Genetic Signals Co-occurring in Inflammatory Diseases and Lung Cancer Risk

2025-10-07 oncology Title + abstract only
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BackgroundNon-small cell lung cancer (NSCLC) frequently co-occurs with chronic inflammatory conditions such as COPD, RA, IPF, psoriasis, and Dermatomyositis. While epidemiological links are established, the genetic basis of this co-occurrence in specific cell types remains poorly resolved. MethodsWe applied a signal-driven colocalization approach to NSCLC GWAS index variants (p < 1 x 10-6), integrating single-cell eQTL (sc-eQTL) data across cell types within {+/-}100 kb windows to identify stab...

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