Back

Lineage Tracing Reveals a Shared Cellular Origin for Supraclavicular Brown and Inguinal Beige Adipocytes

Ran, Y.; Zhang, K.; Shen, Y.-T.; Mo, Q.; Wang, Z.; Yalamanchili, H. K.; John, S.; Kogiso, M.; Gao, X.; Wang, C.; Sinha, T.; Black, B.; Chen, M.-H.

2025-10-03 developmental biology
10.1101/2025.10.02.680118 bioRxiv
Show abstract

The metabolic importance of brown adipose tissue (BAT) has been recognized, but the origins of BAT, particularly supraclavicular BAT (scBAT), are less clear. Here, we traced the origin of scBAT to Mef2c-anterior heart field (AHF)-marked cells. Mef2c-AHF-marked cells isolated from scBAT can spontaneously differentiate into brown adipocytes, express mesenchymal stem cell markers, and can be isolated from the stromal-vascular fraction (SVF) of wild-type scBAT as [CD31-CD45-SCA-1+CD29+CD34-CD24-] (CD34-) cells. Mef2c-AHF-marked cells substantially overlap with Prrx1-marked cells in scBAT, which also contribute to beige adipocytes in inguinal white adipose tissue (iWAT) during development. Similarly, CD34- cells isolated from the SVF of iWAT can spontaneously differentiate into beige adipocytes in vitro. Using intersectional tracing, we revealed that common progenitors of Mef2c-AHF- and Prrx1-marked cells in scBAT emerge from the developing heart. Thus, these studies reveal a common origin for scBAT and cardiac tissue and a close lineage relationship between scBAT and beige adipocytes of the iWAT.

Published in Cell Reports (predicted rank #3) · training set

Matching journals

The top 4 journals account for 50% of the predicted probability mass.

1
eLife
● 5828 papers in training set
Top 3%
18.2%
Similar papers in this journal
2
Nature Communications
○ 5641 papers in training set
Top 10%
18.2%
Similar papers in this journal
Cell Reports · published here
○ 1498 papers in training set
Top 2%
10.5%
Similar papers in this journal
4
Molecular Metabolism
○ 112 papers in training set
Top 0.4%
5.4%
Similar papers in this journal
50% of probability mass above
5
Science Advances
● 1243 papers in training set
Top 7%
4.3%
Similar papers in this journal
6
Cell Stem Cell
○ 62 papers in training set
Top 0.4%
4.0%
7
iScience
○ 1154 papers in training set
Top 8%
3.1%
8
Cell Research
○ 51 papers in training set
Top 0.3%
3.1%
9
npj Regenerative Medicine
○ 24 papers in training set
Top 0.2%
2.7%
10
Cell Metabolism
○ 57 papers in training set
Top 0.5%
2.7%
11
Development
● 497 papers in training set
Top 3%
1.7%
12
Nature Metabolism
○ 69 papers in training set
Top 1%
1.7%
13
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 29%
1.7%
14
Communications Biology
○ 993 papers in training set
Top 19%
1.3%
15
Stem Cell Reports
○ 130 papers in training set
Top 2%
1.1%
16
Cell Death & Differentiation
○ 48 papers in training set
Top 0.9%
1.1%
17
Developmental Cell
○ 196 papers in training set
Top 3%
1.1%
18
EMBO Reports
○ 263 papers in training set
Top 5%
1.1%
19
Cell
○ 431 papers in training set
Top 9%
1.0%
20
Arteriosclerosis, Thrombosis, and Vascular Biology
○ 71 papers in training set
Top 1%
0.9%
21
Stem Cells
◐ 31 papers in training set
Top 0.7%
0.8%
22
Circulation Research
○ 47 papers in training set
Top 1%
0.8%
23
Nature Aging
○ 60 papers in training set
Top 2%
0.8%
24
Science
● 477 papers in training set
Top 9%
0.8%
25
Scientific Reports
○ 3612 papers in training set
Top 77%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.