Translating Deep Learning to Clinical Practice: External Validation and Clinical Benefit of an Electrocardiogram-Based Neural Network for Detecting Low Ejection Fraction

2025-10-08 cardiovascular medicine Title + abstract only

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Low ejection fraction (EF), an indicator of impaired heart function, often goes undiagnosed and can lead to avoidable heart failure and arrhythmias. We developed and externally validated a deep learning model for detecting low EF from 12-lead electrocardiograms. The model achieved 85.8% sensitivity and 83.0% specificity on an independent validation cohort, with consistent results across demographic subgroups. These findings supported FDA 510(k) clearance of the model. Clinical net benefit analys...

Translating Deep Learning to Clinical Practice: External Validation and Clinical Benefit of an Electrocardiogram-Based Neural Network for Detecting Low Ejection Fraction

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