Molecular attributes of intrinsically disordered regions in secretomes influence fungal pathogenesis
Mohapatra, A.; Kadumuri, R. V.; Sharma, A.; Saju, A. P.; Ramadasan, H.; Agrawal, A.; Sharma, V.; Chavali, S.
Show abstract
Secretory proteins are crucial for establishing fungal infection through biomolecular interactions with the host. Accumulating evidence suggest that intrinsically disordered regions (IDRs) in proteins facilitate molecular interactions. How do IDRs of secretory proteins influence fungal pathogenesis? By analyzing 195,359 secretory proteins of 73 fungal species, we find that IDRs in plant pathogen extracellular non-effectors are enriched for weak polyampholytes and polyelectrolytes. These could adopt beads-on-string conformation effectively promoting assembly of diverse enzymes aiding swift degradation of host cell wall. Both animal pathogen secretory proteins and intracellular plant pathogen effectors show enrichment for strong polyampholytes, potentially aiding phase-separation and organizing intracellular biological matter to hijack or suppress host machinery. Importantly, IDRs of plant pathogen effectors which mimic host IDRs could have emerged through convergent evolution, while those of non-effectors might have evolved de novo. Thus, specific molecular attributes of fungal secretome IDRs can influence initiation, establishment and long-term persistence of infection.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Eukaryotic antiviral immune proteins arose via convergence, horizontal transfer, and ancient inheritance 94%
- Disentangling the complex gene interaction networks between rice and the blast fungus identifies a new pathogen effector 93%
- Phylogenomic signatures of repeat-induced point mutations across the fungal kingdom 93%
Similar papers in this journal
- The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interface 92%
- A conserved Guided Entry of Tail-anchored pathway is involved in the trafficking of tail-anchored membrane proteins in Plasmodium falciparum. 92%
- An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments 91%
Similar papers in this journal
Similar papers in this journal
- LectinOracle - A Generalizable Deep Learning Model for Lectin-Glycan Binding Prediction 90%
- Long-read sequencing reveals extensive DNA methylations in human gut phagenome contributed by prevalently phage-encoded methyltransferases 90%
- Mechanical Cues Regulate Cargo Sorting and Export at the Golgi 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.