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Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus
2025-10-02
genetic and genomic medicine
Title + abstract only
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BackgroundC-reactive protein (CRP) is a well-established biomarker of systemic inflammation. In pregnancy, several studies show association of elevated CRP with gestational diabetes mellitus (GDM). However, the genetic contributions of CRP levels during early pregnancy and their potential association with GDM remain largely understudied. MethodsWe conducted maternal and offspring genome-wide association studies (GWAS) of first-trimester CRP levels in the Nulliparous Pregnancy Outcomes Study: Mo...
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