Locally persistent lineages are an important component of zoonotic foodborne pathogen Shiga toxin-producing Escherichia coli O157:H7 disease ecology
Tarr, G. A. M.; Finical, W.; Rounds, J. M.; Panek, A.; Smith, K.
Show abstract
The control of zoonotic foodborne pathogens, including Shiga toxin-producing Escherichia coli (STEC), has proven difficult, in part because we know remarkably little about how these pathogens are maintained in an ecosystem. In response to this gap, we have developed a method for identifying pathogen strains that persistently infect defined human populations, which we call locally persistent lineages (LPLs). Using STEC O157:H7 in Minnesota as a model, we show that LPLs are widespread across the O157 phylogenetic tree, contribute significantly to local disease burden, and can persist for several years. They are also spatially clustered in an area with large populations of cattle, considered O157 STECs primary reservoir. Our results suggest that STEC O157:H7 LPLs are established in ecological niches that support persistence. Identifying LPLs, and ultimately their reservoirs, can advance understanding of their disease ecology and provide opportunities for disease control at both local and national levels.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Phylogeographic clustering of Salmonella enterica serovar Mississippi in the Southeastern United States indicates regional transmission pathways 95%
- Whole-Genome Sequence Typing shows extensive diversity of Listeria monocytogenes in the outdoor environment and poultry processing plants. 93%
- Pervasive Listeria monocytogenes are common in the Norwegian food system and associated with increased prevalence of stress survival and resistance determinants 92%
Similar papers in this journal
- Genomic and Patient Epidemiology of Streptococcus dysgalactiae Subspecies equisimilis in Houston, Texas 94%
- Clinical and genomic epidemiology of mcr - 9 -carrying carbapenem-resistant Enterobacterales isolates in Metropolitan Atlanta, 2012-2017 93%
- From farm to fork: persistence of clinically-relevant multidrug-resistant and copper-tolerant Klebsiella pneumoniae long after colistin withdrawal in poultry production. 92%
Similar papers in this journal
- Phylogenomic analysis of Clostridiodes difficile ribotype 106 strains reveals novel genetic islands and emergent phenotypes 93%
- Inactivation of genes in oxidative respiration and iron acquisition pathways in pediatric clinical isolates of small-colony variant Enterobactericeae 92%
- Global trends in antimicrobial resistance on organic and conventional farms 92%
Similar papers in this journal
- Case-control investigation of invasive Salmonella disease in Africa – comparison of human, animal and household environmental isolates find no evidence of environmental or animal reservoirs of invasive strains 93%
- Seroepidemiology of human leptospirosis in the Dominican Republic: a multistage cluster survey, 2021 93%
- Spatial-temporal and phylogenetic analyses of epidemiologic data to help understand the modes of transmission of endemic typhoid fever in Samoa 92%
Similar papers in this journal
- A 21-year survey of Escherichia coli from bloodstream infections (BSIs) in a tertiary hospital reveals how community-hospital dynamics of the B2 phylogroup clones influence local BSI rates 92%
- Measurement of Klebsiella Intestinal Colonization Density to Assess Infection Risk 92%
- Achromobacter xylosoxidans isolates exhibit genome diversity, variable virulence, high levels of antibiotic resistance and potential intrahost evolution. 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.