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Cuff Algometry Induces Large Yet Variable Conditioned Pain Modulation Effects
2025-10-07
pain medicine
Title + abstract only
View on medRxiv
Show abstract
Conditioned pain modulation (CPM) paradigms provide a proxy measure of activity in the descending pain modulatory system. Cuff-pressure-algometry offers a standardised CPM assessment tool although comprehensive validation in large samples is lacking. To address this, we pooled cuff-algometry CPM data from 324 healthy participants across 8 studies. CPM magnitude was calculated as pain detection (PDT) and tolerance (PTT) threshold changes, assessed on the dominant leg in the presence and absence o...
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