Mapping the Structural Brain Network of Psychopathy: Convergent Evidence from Humans and Chimpanzees
Dugre, J. R.; Vickery, S.; Latzman, R. D.; Hopkins, W. D.; Hoffstaedter, F.; De Brito, S. A.
Show abstract
Psychopathy, a condition characterized by profound emotional and interpersonal deficits, has long been hypothesized to stem, in part, from structural brain abnormalities. Yet neuroimaging findings remain inconsistent. To address these discrepancies, we applied a novel structural network mapping approach combined with cross-species analyses. Traditional meta-analysis revealed weak spatial convergence across 20 samples. Nevertheless, we found that heterogeneous peak locations coalesced into a distributed set of regions encompassing the insular, and prefrontal cortices. This network overlapped strikingly (r = .93) with a lesion-derived network causally linked to antisocial behaviour, and variation within it predicted volumetric risk scores in both humans (n = 107, R{superscript 2} = .16) and chimpanzees (n = 148, R{superscript 2} = .21). These findings suggest that psychopathy reflects abnormalities across a collection of distributed regions rather than isolated areas, providing a unifying explanation for decades of inconsistent results and advancing our understanding of its clinical, biological, and evolutionary bases.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Mapping the coupling between tract reachability and cortical geometry of the human brain 96%
- Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex 96%
- Atypical language network lateralization is reflected throughout the macroscale functional organization of cortex 96%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- The universe is asymmetric, the mouse brain too. 95%
- Altered functional brain dynamics in chromosome 22q11.2 deletion syndrome during facial affect processing 95%
- Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.