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Precision Stratification: Kinase Assay in Asian LRRK2 Risk Carriers and Idiopathic Parkinson Disease

2025-09-25 neurology Title + abstract only
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ImportanceLRRK2 kinase inhibition is one of the most promising therapeutic strategies in Parkinsons disease (PD), yet understanding of kinase activity in the Asian-prevalent p.G2385R and p.R1628P variants, each affecting 5-10% of PD patients, remains limited. Development of patient stratification and target engagement markers applicable across global cohorts is an urgent priority. ObjectiveTo investigate pRab10Thr73 phosphorylation and pLRRK2Ser935 dephosphorylation as markers of in vivo LRRK2 ...

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