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Head direction cells use a head-referenced dual-axis updating rule in 3D space

Williams, M.; Street, J.; Burgess, N.; Jeffery, K.

2025-09-17 neuroscience
10.1101/2025.09.17.676760 bioRxiv
Show abstract

Head direction (HD) cells, comprising a compass signal for the brains spatial map, may update their firing during 3D movement by using a dual axis (DA) rule that summates head rotation around a local axis and local-axis rotation around the gravity axis. To test for operation of this rule we recorded HD cell activity from rats exploring a hemispherical surface. We assessed HD cell tuning curves in either the standard horizontal reference frame or in two reference frames governed by a DA rule, with the local axis referenced to the head (DAH) or local surface (DAS). Tuning curves were best when plotted in the DAH reference frame. This confirms that the cells use a head-referenced DA rule and indicates that the relationship of the head pose to gravity in two planes, one egocentric (head-plane) and one allocentric (earth-horizontal plane), forms a component of the inputs to the HD system.

Published in Communications Biology (predicted rank #10) · training set

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