Back
Top 3%
17.5%
Top 2%
14.4%
Top 2%
7.7%
Top 39%
6.3%
Top 2%
6.3%
Top 77%
5.9%
Top 1%
5.9%
Top 1.0%
5.9%
Top 2%
3.8%
#1
3.8%
Top 3%
1.9%
Top 3%
1.9%
Top 14%
1.5%
Top 15%
1.2%
Top 10%
0.9%
Top 12%
0.9%
Top 68%
0.7%
Top 8%
0.7%
Top 2%
0.7%
A Pan-Cancer Analysis of Lesion-Level Treatment Response to Extend the 'Seed and Soil' Paradigm
2025-09-18
oncology
Title + abstract only
View on medRxiv
Show abstract
BackgroundThe classical "seed and soil" hypothesis suggests that metastatic spread is shaped by tumor-intrinsic traits ("seeds") and the organ-specific microenvironment ("soil"). We expand this concept to explain lesion-level therapeutic responses and phenotypic variability across metastatic cancers. MethodsWe analyzed 55,220 lesions from 6,087 patients enrolled in 20 clinical trials across six cancer types. Using nonlinear mixed-effects modeling, we estimated lesion-specific parameters: regres...
Predicted journal destinations
1
Nature Communications
483 training papers
2
Cancers
57 training papers
3
eLife
262 training papers
4
Scientific Reports
701 training papers
5
Frontiers in Oncology
34 training papers
6
PLOS ONE
1737 training papers
7
Clinical Cancer Research
22 training papers
8
Proceedings of the National Academy of Sciences
100 training papers
9
British Journal of Cancer
22 training papers
10
Cell Reports
25 training papers
11
BMC Cancer
21 training papers
12
Cancer Medicine
17 training papers
13
JAMA Network Open
125 training papers
14
npj Digital Medicine
85 training papers
15
iScience
74 training papers
16
PLOS Computational Biology
141 training papers
17
BMJ Open
553 training papers
18
Communications Medicine
63 training papers
19
International Journal of Cancer
18 training papers