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More severe history of childhood adversity is linked to greater surface area of induced secondary hyperalgesia
2025-09-18
pain medicine
Title + abstract only
View on medRxiv
Show abstract
Childhood adversity is linked to persistent pain in adulthood. Nociceptive upregulation may play a role in this relationship. We investigated whether childhood adversity is associated with measures of nociceptive processing, and whether these associations differ by sex. In this experimental observational study, we enrolled pain-free adults with varying severity of childhood adversity, scored on the Childhood Trauma Questionnaire-Short Form. Measures of nociceptive processing included the surface...
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