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Nampt Inhibition Selectively Targets Mds Myeloblasts In High-Risk Mds With Monosomy 7 Or Del(7Q)
2025-09-15
hematology
Title + abstract only
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Monosomy 7 and deletion of the q arm of chromosome 7 (-7/-7q) are high-risk markers in myelodysplastic syndromes (MDS). We previously showed that blasts with -7/-7q from patients with acute myeloid leukemia (AML) are exceptionally sensitive to NAMPT inhibitors, with the sensitivity caused by NAMPT gene haploinsufficiency as a result of - 7/-7q. The objective of this study was to investigate whether blasts from patients with -7/-7q MDS are similarly susceptible to NAMPT inhibition. We first asses...
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