Human CDK5-cyclin B1 structures uncover a conserved mitotic CDK activation mechanism
Syed, A.; Arvai, A. S.; Cong, K.; Zheng, X.-F.; Verway-Cohen, A.; Tsai, M.-S.; Nguyen, H.; Bacolla, A.; Tsai, C.-L.; Lantz, G.; Spektor, A.; Chowdhury, D.; Tainer, J. A.
Show abstract
Cyclin-dependent kinase 5 (CDK5), long considered atypical and activated by non-cyclin cofactors in neurons, also functions in mitosis. To resolve its activation mechanism during mitosis, we determined the first high-resolution crystal structures of CDK5-cyclin B1 in apo and nucleotide-bound states. Contrary to AlphaFold predictions, we find CDK5 structures unexpectedly mirrors CDK1-cyclin B1 assembly and activation, establishing CDK5 as a bona fide mitotic kinase acting in parallel with CDK1.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.