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Non-linear Mendelian randomization of vitamin D and C-Reactive Protein: an interrogation of methods
2025-09-12
epidemiology
Title + abstract only
View on medRxiv
Show abstract
Mendelian randomization (MR) is an established epidemiological technique which uses genetic variants to strengthen causal inference regarding modifiable exposures. Non-linear MR is an extension to MR which aims to estimate whether the effect differs across the level of the exposure. Many applications of non-linear MR have focused on Vitamin D as an exposure. Using this technique, the study sample is divided into strata, and separate estimates are calculated in each stratum to estimate causal eff...
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