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Direct effect of genetic ancestry on complex traits in a Mexican population

2025-09-10 genetic and genomic medicine Title + abstract only
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Human populations differ in disease prevalences and in average values of phenotypes, but the extent to which differences are caused by genetic or environmental factors is unknown for most complex traits. Comparing phenotypic means across populations is confounded by environmental differences and comparisons based on polygenic predictors can lead to biased inference1,2. Family-based analyses of genetically admixed individuals offer a powerful framework for disentangling the direct and associated ...

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