Dopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis
Lo Piccolo, L.; Yeewa, R.; Noisagul, P.; Monteil, A.; Shotelersuk, V.; Jantrapirom, S.
Show abstract
YEATS2 is a ubiquitously expressed chromatin-associated factor that we recently identified as a novel regulator of dopaminergic (DAergic) synaptic integrity, though its mechanism of action remained unclear. Using Drosophila, we show that neuronal depletion of YEATS2 reshapes the brain transcriptome, marked by downregulation of metabolic genes and upregulation of G protein-coupled receptors (GPCRs). These changes coincide with elevated intracellular calcium, neurobehavioral deficits, and selective DA neuron loss. Importantly, genetic or pharmacological inhibition of the store-operated calcium entry channel Orai restored calcium homeostasis and rescued DA neuron survival. Our findings define a YEATS2-dependent epigenetic-calcium axis that governs DA neuron vulnerability.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Orai mediated Calcium entry determines activity of central dopaminergic neurons by regulation of gene expression 97%
- Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity 97%
- The GPI-anchored Ly6 protein Belly roll regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons 96%
Similar papers in this journal
- Simultaneous suppression of ribosome biogenesis and Tor activation by TRIM-NHL proteins promotes terminal differentiation 95%
- Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest 95%
- Replication competition drives the selective mtDNA inheritance in Drosophila ovary 95%
Similar papers in this journal
- Maintenance of cell type-specific connectivity and circuit function requires Tao kinase 96%
- A neural m6A/YTHDF pathway is required for learning and memory in Drosophila 95%
- The ubiquitin ligase Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles 95%
Similar papers in this journal
Similar papers in this journal
- Neural connectivity molecules best identify the heterogeneous clock and dopaminergic cell types in the Drosophila adult brain 95%
- Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes 95%
- Neuropeptide Dynamics Coordinate Layered Plasticity Mechanisms Adapting Drosophila Circadian Behavior to Changing Environment. 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.