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Effectiveness of 2024/25 KP.2 vaccine against outpatient COVID-19 in Canada

Separovic, L.; Sabaiduc, S.; Zhan, Y.; Kaweski, S. E.; Carazo, S.; Olsha, R.; Mather, R. G.; Lacroix, C.; Hasso, M.; Levade, I.; Meunier, I.; Jassem, A. N.; Dover, K.; Gao, R.; Bastien, N.; Skowronski, D. M.

2025-09-11 public and global health
10.1101/2025.09.05.25335203 medRxiv
Show abstract

Between November 2024 and April 2025, the Canadian Sentinel Practitioner Surveillance Network assessed KP.2 vaccine effectiveness against outpatient COVID-19 by test-negative design. Vaccination protected best during the first two months, reducing risk by two-thirds among vaccinated versus unvaccinated individuals, declining by 3-4 months, and reducing the risk overall by half.

Published in Influenza and Other Respiratory Viruses (predicted rank #3) · training set

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